Quebec Mathematical Sciences Colloquium

June 19, 2020 from 16:00 to 17:00 (Montreal/Miami time) Zoom meeting

Quantitative approaches to understanding the immune response to SARS-CoV-2 infection

Colloquium presented by Morgan Craig (Université de Montréal)

COVID-19 is typically characterized by a range of respiratory symptoms that, in severe cases, progress to acute respiratory distress syndrome (ARDS). These symptoms are also frequently accompanied by a range of inflammatory indications, particularly hyper-reactive and dysregulated inflammatory responses in the form of cytokine storms and severe immunopathology. Much remains to be uncovered about the mechanisms that lead to disparate outcomes in COVID-19. Here, quantitative approaches, especially mechanistic mathematical models, can be leveraged to improve our understanding of the immune response to SARS-CoV-2 infection.

Building upon our prior work modelling the production of innate immune cell subsets and the viral dynamics of HIV and oncolytic viruses, we are developing a quantitative framework to interrogate open questions about the innate and adaptive immune reaction in COVID-19. In this talk, I will outline our recent work modelling SARS-CoV-2 viral dynamics and the ensuing immune response at both the tissue and systemic levels. A portion of this work is done as part of an international and multidisciplinary coalition working to establish a comprehensive tissue simulator (physicell.org/covid19 [1]), which I will also discuss in more detail.

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